Tadalafil 40 mg (Cialis): treating ED.

tadalafil at 40 mg is used primarily for the following purposes:

1. Treatment of erectile dysfunction (ED)

Mechanism for action:

-Tadalafil inhibits the enzyme phosphodiesterase type 5 (PDE-5). This enzyme is responsible for degrading nitrogen monoxide (no)-cyclic monophosphate dependent guanosin (cGMP) in the smooth vascular muscle of the penis. By inhibiting PDE-5, tadalafil increases cGMP concentration, leading to smooth muscle relaxation and increased blood flow to the penis, facilitating erection.

-unlike some other drugs for ED, tadalafil has a long duration of action. At a dose of 40 mg, it can have an effect for approximately 36 hours in some patients, known as the prolonged therapeutic window. This offers greater flexibility in planning sexual activity compared to drugs with a shorter duration of action.

2. Treatment of benign prostate hypertrophy (HBP)

Mechanism of action in HBP:

-in HBP, tadalafil works by relaxing the smooth muscle of the lower urinary tract (UI), including the prostate and bladder. This helps relieve urinary symptoms associated with PPH, such as difficulty starting urination, interrupted urination, a feeling of not completely emptying the bladder, and an excessive urinary frequency.

-the 40 mg dose may contribute to improving symptomatology and urinary function in patients with PPH, and in some cases may be combined with other drugs for more comprehensive treatment.

However, tadalafil should be prescribed and used under medical supervision, as it may have interactions with other medicines and contraindications in patients with certain cardiovascular diseases, for example.