Tadalafil for what?

Tadalafil is primarily used for the following purposes:

1. Treatment of erectile dysfunction (ED)

Mechanism for action:

-Tadalafil inhibits the enzyme phosphodiesterase-5 (PDE-5). This enzyme is responsible for degrading nitrogen monoxide (no)-cyclic monophosphate dependent guanosin (cGMP) in penile cavernous tissue. By inhibiting PDE-5, the concentration of cGMP is increased, resulting in a relaxation of smooth muscles in the penis, allowing greater blood flow and facilitating erection.

Effectiveness:

-help men with SD achieve and maintain sufficient erections for satisfactory sexual activity.

2. Treatment of pulmonary hypertension (HP)

Mechanism for action:

-in pulmonary hypertension, tadalafil works by relaxing the muscles of the pulmonary blood vessels. By inhibiting PDE-5 in pulmonary vessels, the concentration of cGMP is increased, resulting in vasodilation. This reduces pulmonary blood pressure and makes it easier for the heart to pump blood into the lungs.

Effectiveness:

-it can improve the functional capacity and quality of life of patients with pulmonary hypertension, relieving symptoms such as dyspnea (shortness of air) and fatigue.

It is important to note that tadalafil should be prescribed by a doctor and consideration should be given to possible interactions with other medicines and contraindications, such as in patients with certain serious heart problems or who are taking nitrates, as the combination can lead to a dangerous drop in blood pressure.