Tadalafil (Cialis): treating Erectile Dysfunction by muscle relaxation

Tadalafil is primarily used for the following purposes:

1. Treatment of erectile dysfunction (ED)

Mechanism for action:

-Tadalafil inhibits the type 5 phosphodiesterase enzyme (PDE-5), which is responsible for degrading nitrogen monoxide (no)-dependent on cyclic monophosphate guanosin (cGMP) in penile cavernous tissue. By inhibiting PDE-5, the concentration of cGMP is increased, resulting in relaxation of the smooth muscles of cavernous tissue and allowing greater blood flow to the penis, facilitating erection.

Effectiveness:

-it has been shown to be effective in numerous clinical studies to improve the ability of men with SD to achieve and maintain an erection sufficient for sexual activity.

2. Treatment of pulmonary hypertension (HP)

Mechanism for action:

-in HP, tadalafil works by relaxing the muscles of the pulmonary blood vessels. By inhibiting PDE-5 in these vessels, the concentration of cGMP is increased, leading to pulmonary vasodilation. This reduces pulmonary blood pressure, improving cardiac function and exercise capacity in patients with HP.

Effectiveness:

-it has been shown to improve symptomatology, cardiac function, and survival in some patients with pulmonary hypertension.

It is important to note that tadalafil should be prescribed by a doctor and consideration should be given to possible interactions with other medicines and contraindications, such as in patients with severe hypotension, serious heart problems or those taking nitrate medicines, as the combination with nitrates can cause a drastic drop in blood pressure.